CALL FOR PAPERS Physiology and Pharmacology of Temperature Regulation Exercise can be pyrogenic in humans

Bradford, Carl D., James D. Cotter, Megan S. Thorburn, Robert J. Walker, and David F. Gerrard. Exercise can be pyrogenic in humans. Am J Physiol Regul Integr Comp Physiol 292: R143–R149, 2007. First published August 3, 2006; doi:10.1152/ajpregu.00926.2005.—Exercise increases mean body temperature ( Tbody) and cytokine concentrations in plasma. Cytokines facilitate PG production via cyclooxygenase (COX) enzymes, and PGE2 can mediate fever. Therefore, we used a COX-2 inhibitor to test the hypothesis that PG-mediated pyrogenicity may contribute to the raised T body in exercising humans. In a double-blind, cross-over design, 10 males [age: 23 yr (SD 5), V̇O2 max: 53 ml kg 1 min 1 (SD 5)] consumed rofecoxib (50 mg/day; NSAID) or placebo (PLAC) for 6 days, 2 wk apart. Exercising thermoregulation was measured on day 6 during 45-min running ( 75% V̇O2 max) followed by 45-min cycling and 60-min seated recovery (28°C, 50% relative humidity). Plasma cytokine (TNF, IL-10) concentrations were measured at rest and 30-min recovery. T body was similar at rest in PLAC (35.59°C) and NSAID (35.53°C) and increased similarly during running, but became 0.33°C (SD 0.26) lower in NSAID during cycling (37.39°C vs. 37.07°C; P 0.03), and remained lower throughout recovery. Sweating was initiated at T body of 35.6°C in both conditions but ceased at higher T body in PLAC than NSAID during recovery [36.66°C (SD 0.36) vs. 36.39°C (SD 0.27); P 0.03]. Cardiac frequency averaged 6 min 1 higher in PLAC (P 0.01), whereas exercising metabolic rate was similar (505 vs. 507 W m ; P 0.56). A modest increase in both cytokines across exercise was similar between conditions. COX-2 specific NSAID lowered exercising heat and cardiovascular strain and the sweating (offset) threshold, independently of heat production, indicating that PGE-mediated inflammatory processes may contribute to exercising heat strain during endurance exercise in humans.